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Rosuvastatin Side Effects

Rosuvastatin is the most recent FDA-approved statin (doses 5-40 mg) for the treatment of dys- lipidemia. Rosuvastatin, which has a structure similar to other synthetic statins, has a long half- life (20-24 hours) similar to atorvastatin and hydrophilicity comparable to pravastatin (95). Consequently, rosuvastatin is minimally metabolized and has no significant cytochrome P450 drug interactions. The efficacy of rosuvastatin is superior to that of other statins (96). Compared to atorvastatin, rosuvastatin provides approximately an 8% additional lowering of LDL-C on an equivalent dose level (96). This provides modestly more efficacy than a doubling of the dose of atorvastatin. Rosuvastatin also increases HDL-C slightly more than atorvastatin, especially at the highest doses (96). The safety of rosuvastatin at doses of 5 to 10 mg is comparable to that of other statins in regard to liver function abnormalities and myopathy rates (97). The lack of cytochrome P450 metabolism for rosuvastatin allows this therapy to be used without precautions in patients who are on cytochrome P450 3A4-inhibiting drugs such as amiodarone, nefazodone, or ketoconazole. As compared to gemfibrozil, rosuvastatin has been shown not to have a pharmacokinetic inter- action with fenofibrate. Therefore, the usual caution regarding the concomitant use of statin and fibrates may not apply with the combination of rosuvastatin and fenofibrate. Both gemfibrozil and cyclosporin significantly increase the area under the curve for rosuvastatin. In combination with these drugs, rosuvastatin should be initiated at the 5 mg dose and should not exceed 10 mg.

What should my health care professional know before I take Rosuvastatin?

They need to know if you have any of these conditions

■  an alcohol problem

■  diabetes mellitus

■  infection

■  kidney disease

■  liver disease

■  low Mood pressure

■  muscle disorder or condition

■  recent surgery

■  seizures (convulsions)

■  .severe injury

■  an unusual reaction to rosuvastatin, medicines, foods, dyes, or preservatives

■  pregnant of trying to get pregnant

■  breast-feeding


What side effects may I notice from taking rosuvastatin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or uncommon rosuvastatin side effects:

■ blurred vision, or vision changes

■ dark yellow or brown urine

■ decreased urination, difficulty passing urine

■ fever

■ muscle pain, tenderness, cramps, or weakness

■ skin rash, itching

■ unusual tiredness or weakness
■    yellowing of (he skin or eyes

Rosuvastatin side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

■ constipation or diarrhea

■ difficulty sleeping

■ dizziness

■ headache

■ nausea, vomiting

■ stomach pain or indigestion